Study of a Hydrophilic Healing-Promoting Porcine Acellular Dermal Matrix

Sodium hyaluronate (SH) is recognized as the strongest natural humectant, since it contains a large number of hydroxyl and carboxyl groups in its structure, can absorb 1000 times own weight water. The porcine acellular dermal matrix (pADM) has been widely used biological materials for activities, such promoting cell proliferation wound healing. Enhancing hydrophilic moisturizing properties pADM expected to further improve ability promote However, there are no strong chemical bonds between SH pADM. Therefore, was oxidized by sodium periodate this study, cross-link with microstructure, hydrophilicity, moisture retention, degradation cytotoxicity cross-linked different oxidation degrees (OSH) were studied. results show that OSH-pADM maintained secondary structure collagen, well good microporous native after cross-linking. With increasing degree, surface hydrophilicity retention capacities increased; among them, 40% degree OSH found have capacity. hygroscopic kinetics at 93% RH conformed second-order equation, indicating process controlled factors. resistance also increased acceptable. vivo full-thickness healing experiments showed had an obvious It be speculated OSH-pADM, properties, physicochemical biocompatibility, great potential facilitating repair.